Sphingolipid signaling in yeast: potential implications for understanding disease.
Identifieur interne : 000F76 ( Main/Exploration ); précédent : 000F75; suivant : 000F77Sphingolipid signaling in yeast: potential implications for understanding disease.
Auteurs : Sharon Epstein [Suisse] ; Howard RiezmanSource :
- Frontiers in bioscience (Elite edition) [ 1945-0508 ] ; 2013.
Descripteurs français
- KwdFr :
- Complexe-2 cible mécanistique de la rapamycine (MeSH), Complexes multiprotéiques (métabolisme), Modèles biologiques (MeSH), Points de contrôle du cycle cellulaire (physiologie), Pression osmotique (physiologie), Réaction de choc thermique (physiologie), Saccharomyces cerevisiae (MeSH), Sphingolipides (biosynthèse), Sphingolipides (métabolisme), Sphingolipides (physiologie), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (physiologie).
- MESH :
- biosynthèse : Sphingolipides.
- métabolisme : Complexes multiprotéiques, Sphingolipides, Sérine-thréonine kinases TOR.
- physiologie : Points de contrôle du cycle cellulaire, Pression osmotique, Réaction de choc thermique, Sphingolipides, Transduction du signal.
- Complexe-2 cible mécanistique de la rapamycine, Modèles biologiques, Saccharomyces cerevisiae.
English descriptors
- KwdEn :
- Cell Cycle Checkpoints (physiology), Heat-Shock Response (physiology), Mechanistic Target of Rapamycin Complex 2 (MeSH), Models, Biological (MeSH), Multiprotein Complexes (metabolism), Osmotic Pressure (physiology), Saccharomyces cerevisiae (MeSH), Signal Transduction (physiology), Sphingolipids (biosynthesis), Sphingolipids (metabolism), Sphingolipids (physiology), TOR Serine-Threonine Kinases (metabolism).
- MESH :
- chemical , biosynthesis : Sphingolipids.
- chemical , metabolism : Multiprotein Complexes, Sphingolipids, TOR Serine-Threonine Kinases.
- chemical , physiology : Sphingolipids.
- chemical : Mechanistic Target of Rapamycin Complex 2.
- physiology : Cell Cycle Checkpoints, Heat-Shock Response, Osmotic Pressure, Signal Transduction.
- Models, Biological, Saccharomyces cerevisiae.
Abstract
Sphingolipids are essential components of membranes and important for cellular integrity. The main focus of research in the past years has been to demonstrate their role as second messengers. The yeast Saccharomyces cerevisiae is an excellent model for the study of sphingolipids, because the first steps of this metabolic pathway are highly conserved among fungal, plant and the animal kingdoms. The yeast model is a valuable system for the understanding of pathways and development of tools that will help to better understand and intervene into the molecular mechanisms controlling health and disease. Different classes of sphingolipids have been shown to act in different pathways. Sphingoid bases were shown to be involved in protection against a series of stresses such as heat shock, osmotic stress and low pH. Ceramides have been shown to be involved in G1 arrest, heat shock response and more recently as a target of the TORC 2. Complex sphingolipids are essential for cell wall integrity and proper localization of GPI anchored proteins.
DOI: 10.2741/e599
PubMed: 23276973
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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The main focus of research in the past years has been to demonstrate their role as second messengers. The yeast Saccharomyces cerevisiae is an excellent model for the study of sphingolipids, because the first steps of this metabolic pathway are highly conserved among fungal, plant and the animal kingdoms. The yeast model is a valuable system for the understanding of pathways and development of tools that will help to better understand and intervene into the molecular mechanisms controlling health and disease. Different classes of sphingolipids have been shown to act in different pathways. Sphingoid bases were shown to be involved in protection against a series of stresses such as heat shock, osmotic stress and low pH. Ceramides have been shown to be involved in G1 arrest, heat shock response and more recently as a target of the TORC 2. Complex sphingolipids are essential for cell wall integrity and proper localization of GPI anchored proteins.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23276973</PMID><DateCompleted><Year>2013</Year><Month>06</Month><Day>05</Day></DateCompleted><DateRevised><Year>2019</Year><Month>11</Month><Day>12</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1945-0508</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><PubDate><Year>2013</Year><Month>Jan</Month><Day>01</Day></PubDate></JournalIssue><Title>Frontiers in bioscience (Elite edition)</Title><ISOAbbreviation>Front Biosci (Elite Ed)</ISOAbbreviation></Journal><ArticleTitle>Sphingolipid signaling in yeast: potential implications for understanding disease.</ArticleTitle><Pagination><MedlinePgn>97-108</MedlinePgn></Pagination><Abstract><AbstractText>Sphingolipids are essential components of membranes and important for cellular integrity. The main focus of research in the past years has been to demonstrate their role as second messengers. The yeast Saccharomyces cerevisiae is an excellent model for the study of sphingolipids, because the first steps of this metabolic pathway are highly conserved among fungal, plant and the animal kingdoms. The yeast model is a valuable system for the understanding of pathways and development of tools that will help to better understand and intervene into the molecular mechanisms controlling health and disease. Different classes of sphingolipids have been shown to act in different pathways. Sphingoid bases were shown to be involved in protection against a series of stresses such as heat shock, osmotic stress and low pH. Ceramides have been shown to be involved in G1 arrest, heat shock response and more recently as a target of the TORC 2. 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